One more research paper hot off the press:
https://journals.lww.com/annalsofsurgery/fulltext/2024/09000/benefits_of_aerosolized,_point_of_care,_autologous.11.aspx
Objective:
To determine the utility of Autologous Skin Cell Suspension (ASCS) in closing full-thickness (FT) defects from injury and infection.
Background:
Although ASCS has documented success in closing partial-thickness burns, far less is known about the efficacy of ASCS in FT defects.
Methods:
Fifty consecutive patients with FT defects (burn 17, necrotizing infection 13, crush 7, degloving 5, and other 8) underwent closure with the bilayer technique of 3:1 widely meshed, thin, split-thickness skin graft and 80:1 expanded ASCS. End points were limb salvage rate, donor site reduction, operative and hospital throughput, incidence of complications, and re-epithelialization by 4, 8, and 12 weeks.
Results:
Definitive wound closure was achieved in 76%, 94%, and 98% of patients, at 4, 8, and 12 weeks, respectively. Limb salvage occurred in 42/43 patients (10 upper and 33 lower extremities). The mean area grafted was 435 cm2; donor site size was 212 cm2, representing a potential reduction of 50%. The mean surgical time was 71 minutes; the total operating room time was 124 minutes. The mean length of stay was 26.4 days; the time from grafting to discharge was 11.2 days. Four out of 50 patients (8%) required 6 reoperations for bleeding (1), breakdown (4), and amputation (1). Four out of 50 patients (8%) developed hypertrophic scarring, which responded to silicone sheeting (2) and laser resurfacing (2). The mean follow-up was 92.7 days.
Conclusions:
When used for the closure of FT wounds, point-of-care ASCS is effective and safe. Benefits include rapid re-epithelialization, high rate of limb salvage, reduction of donor site size and morbidity, and low incidence of hypertrophic scarring.
Ref: Papers of the 144th ASA Annual MeetingBenefits of Aerosolized, Point-of-care, Autologous Skin Cell Suspension (ASCS) for the Closure of Full-thickness Wounds From Thermal and Nonthermal CausesLearning Curves From the First 50 Consecutive Cases at an Urban, Level 1 Trauma CenterHultman, C. Scott MD, MBA*; Adams, Ursula C. MD, MBA†; Rogers, Corianne D. MD*; Pillai, Minakshi MS†; Brown, Samantha T. PA-C*; McGroarty, Carrie Ann PA-C*; McMoon, Michelle PA-C, PhD*; Uberti, M. Georgina MD‡Author InformationAnnals of Surgery 280(3)
452-462, September 2024. | DOI: 10.1097/SLA.0000000000006387
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