research article link

http://www.springerplus.com/content/pdf/2193-1801-2-324.pdf

Not sure what most of the content contained in the above link means but I found the following paragraph interesting.

"What are the biological consequences of the interaction with the water exposed sites of the protein? It has been shown, that residues in the loop region, Lys-33 and Arg-35, are important for the functioning of the protein (Steinmann et al. 2007b). Binding of any drug via interacting with the backbone of the protein would hamper the dynamics of the loop and with it, possibly, the free energy involved in the mechanism of function. In the specific case of BIT225, the interaction is indeed identified to be with the backbone of the highly important residues Arg-35. This may explain the successful antiviral activity of this compound compared to amantadine and one of its derivatives."

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