PAR 2.17% 23.5¢ paradigm biopharmaceuticals limited..

Hmm looking at the following table from a different website...

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    Hmm looking at the following table from a different website there were some AE's..though the commentary here suggests that overall it has a "favorable" safety profile? Wern't there like 4 deaths out of a sample of 2000 and a heap of Serious TEAE's?????

    Maybe I'm not reading it right, here is the link:


    https://acrabstracts.org/abstract/rheumatoid-arthritis-treatment-with-filgotinib-week-132-safety-data-from-a-phase-2b-open-label-extension-study/


    I would like to see PPS's comparative table, I don't think we have had any AE's. Maybe a few upset stomachs and the odd headache and a little bruising around the injection site, cosmetic effects at best?

    If Filgtiib has a favorable profile surely ours is 'very favorable' or even 'out of this world favorable' (sorry, I'm being flippant)

    Here is the table I'm referring to for Filgotinib.

    Conclusion:

    Filgotinib continues to demonstrate a favorable safety and tolerability profile in pts with RA over a 2.5-year period, with maintenance of therapeutic response in the long-term.

    Table 1: Key Safety Events Per 100 PYE


    Filgotinib (200mg daily) + MTX

    Filgotinib (200mg daily) Monotherapy

    Total*

    PYE=1443

    PYE=599

    PYE=2042

    Treatment-emergent AEs (TEAEs)

    144.1

    151.5

    146.3

    Serious TEAEs

    5.1

    6.8

    5.6

    TEAEs for Infections

    41.6

    36

    40

    Serious TEAEs for Infections

    0.8

    1.7

    1

    Malignancy (excluding NMSC)

    0.6

    0.7

    0.6

    Herpes Zoster

    1.5

    1.5

    1.5

    Deep Vein Thrombosis

    0.07

    0

    0.05

    Pulmonary Embolism

    0.07

    0

    0.05

    Active Tuberculosis

    0

    0

    0

    Deaths

    0.1

    0.5

    0.2

    *Treatment groups with fewer than 10 subjects were omitted for clarity;Non-melanoma skin cancer;
    Single patient DVT leading to PE.

 
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