Note that H275Y is the same gene as H274Y (there are 2 systems...

Note that H275Y is the same gene as H274Y (there are 2 systems of naming the gene!! I think that H274Y is the more commonly used,

Below are some recent comments on the H274Y in seasonal flu in 2007/08 and 2008/09 and emerging resistance in H1N1 Swine Flu from Dr Henry Niman on the FluTrackers site.


Regards
Kangaroo1


http://fluboard.rhizalabs.com/forum/viewtopic.php?p=42164#p42164

Regarding sesonal flu:

- " However in the 2007/2008 season many countries, including the US and UK, had relative low frequencies of H274Y (around 10%). H274Y approached 100% of H1N1 in the summer of 2008 in the southern hemisphere and the continued at 100% in the northern hemisphere in the 2008/2009 season, so additional changes....drove the frequency to 100%.

However, seasonal H1N1 has been crowded out by pandemic H1N1. so H274Y in seasonal H1N1 will not be a clinical issue. However, H274Y has emerged in pH1N1, including evolutionary fit isolates from Hong Kong (ex-San Francisco), Vietnam, and Israel. ...... Moreover, almost all 2010 sequences from Japan have H274Y, indicating it is fit and transmitting......" END