TC
I wish I knew but like the Chair/CEO machinations I’m just guessing. Having said that I’ll give it a crack and say that yes they would at least want a decent indication of the 008 results before partnering, I think the main purpose of 008 is to add value to the asset in negotiations - it’s not needed as a registration trial but will add value to the label.
There is one thing really worth noting and it’s kinda massive…..
008 gives a “look through” to the P3 results (“getting the results before the exam” sound familiar!!!). Just like SAS predicated P2. I definitely recall PR explicitly saying this in a presentation some time ago as the rationale for 008
008 has WOMAC as a secondary endpoint (and this is the primary endpoint for P3). So after only 56 days of treating the last 008 patient we kinda have a model of what the P3 primary endpoint looks like.
The P2 was a KOOS score and we’ve done some SAS work with WOMAC (not placebo controlled). But I think 008 is the first time we’ve used WOMAC to test against placebo,
So can you imagine negotiating with a pharma and saying - “yes we are in P3 and here are the results!” Pretty strong position I’d say. So I reckon once we get a read on the results it will assist negotiations
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