Methods and compositions for RNA interference Abstract
The present invention provides methods for attenuating gene expression in a cell, especially in a mammalian cell, using gene-targeted double stranded RNA (dsRNA), such as a hairpin RNA. The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the "target" gene).
Inventors:
Hannon; Gregory J. (Huntington, NY), Paddison; Patrick (Oyster Bay, NY), Bernstein; Emily (New York, NY), Caudy; Amy (Lawrenceville, NJ), Conklin; Douglas (Cold Spring Harbor, NY), Hammond; Scott (Cold Spring Habor, NY)
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Assignee:
Cold Spring Harbor Laboratory (Cold Spring Harbor, NY)