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Originally posted by hottod: ↑

Valproate is one of the most commonly prescribed medications for epileptic seizures suffered by individuals with Rett syndrome. Valproate products have been approved by the FDA.

Information on some of the more serious and more common adverse events associated with use of valproate products are listed below.

Anyone worried about the side effect profile of trofinetide should have a read.

Valproic acid may cause serious or life-threatening damage to the liver that is most likely to occur within the first 6 months of therapy.

Valproic acid can cause serious birth defects (physical problems that are present at birth), especially affecting the brain and spinal cord and can also cause lower intelligence and problems with movement and coordination, learning, communication, emotions, and behavior in babies exposed to valproic acid before birth.

Valproic acid may cause serious or life-threatening damage to the pancreas. This may occur at any time during your treatment.

Valproic acid may help to control your condition but will not cure it. Continue to take valproic acid even if you feel well. Do not stop taking valproic acid without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood or if you find out that you are pregnant. If you suddenly stop taking valproic acid, you may experience a severe, long-lasting and possibly life-threatening seizure. Your doctor will probably decrease your dose gradually.

https://medlineplus.gov/druginfo/meds/a682412.html

Cardiovascular
Common (1% to 10%): Edema, hypertension, hypotension, palpitations postural hypotension, peripheral edema, tachycardia, vasodilation

Psychiatric
Very common (10% or more): Nervousness
Common (1% to 10%): Abnormal dreams, agitation, anxiety, aggression, confusion, depression, emotional lability, hallucinations, insomnia, personality disorder, thinking abnormalities

Respiratory
Very common (10% or more): Flu syndrome, respiratory infection
Common (1% to 10%): Bronchitis, dyspnea, epistaxis, increased cough, pharyngitis, pneumonia, rhinitis, sinusitis

Dermatologic
Very common (10% or more): Alopecia
Common (1% to 10%): Discoid lupus erythematosus, dry skin, ecchymosis, furunculosis, maculopapular rash, petechia, pruritus, rash, seborrhea

Gastrointestinal
Very common (10% or more): Abdominal pain, diarrhea, dyspepsia, gingival disorder, nausea, vomiting
Common (1% to 10%): Constipation, dry mouth, eructation, fecal incontinence, flatulence, gastralgia, gastroenteritis, glossitis, periodontal abscess, hematemesis, stomatitis

Genitourinary
Common (1% to 10%): Amenorrhea, cystitis, dysmenorrhea, dysuria, enuresis, metrorrhagia, urinary incontinence, urinary frequency, vaginal hemorrhage, vaginitis

Hematologic
Very common (10% or more): Thrombocytopenia
Common (1% to 10%): Anemia, hemorrhage

Hepatic
Common (1% to 10%): Increased liver enzymes (particularly early in treatment), liver injury, SGOT increased, SGPT increased

Local
Common (1% to 10%): Injection site pain, injection site reaction

Metabolic
Very common (10% or more): Anorexia
Common (1% to 10%): Weight loss/gain, increased appetite, hyponatremia

Musculoskeletal
Common (1% to 10%): Arthralgia, arthrosis, leg cramps, myalgia, myasthenia, twitching

Nervous system
Very common (10% or more): Dizziness, headache, somnolence, tremor
Common (1% to 10%): Abnormal gait, amnesia, catatonic reaction, convulsion, disturbance in attention, dysarthria, extrapyramidal disorder, hypertonia, hypokinesia, incoordination, increased reflexes, memory impairment, nystagmus, paraesthesia, speech disorder, stupor, tardive dyskinesia, taste perversion

Ocular
Very common (10% or more): Amblyopia/blurred vision, diplopia
Common (1% to 10%): Abnormal vision, conjunctivitis, diplopia, dry eyes, eye pain

Other
Very common (10% or more): Asthenia
Common (1% to 10%): Back pain, chills, deafness, ear disorder, ear pain, face edema, fever, malaise, otitis media, tinnitus, vertigo

https://www.drugs.com/sfx/valproate-sodium-side-effects.html#consumer

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Interesting.
Don’t think there was any mention on frequency of seizures in the trials. Wonder if Trofinetide could have an effect on reducing seizures as it was shown to do so in brain injury trials.
I can assume the mechanism of epileptic seizures is different to that of seizures as a result of brain injury however it would be interesting to see if a correlation may exist.

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