This has been the institutional response from investors. Many I have spoken too reduced their stakes leading upto these results on this basis. The consensus is about 1/3rd reduction. Remember that institutional investors have to mark-to-market for their investors on a monthly basis and thus have a different investor horizon.
I also spoke with Cafa about this.
Some investors are happy to hold anyway as the ASCO results on June 6th are much more powerful going forward for long-term investor returns from the sales potential of Sirspheres
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