Reading into the whole process a little further with NASA, how this is bigger than just IIH and why they chose IIH first to prove the concept works;
Exanetide is an antagonist which binds the GLP-1 receptor and this reduces cerebrospinal fluid secretion CFS.
"Most of the astronauts onboard the International Space Station (ISS) develop visual impairment and ocular structural changes that are not fully reversible upon return to earth. Current understanding assumes that the so-called visual impairments/intracranial pressure (VIIP) syndrome is caused by cephalad vascular fluid shift. This study assesses the roles of cerebrospinal fluid (CSF) and intracranial pressure (ICP) in VIIP." "These findings are evidence for the primary role of CSF and a lesser role for intracranial cephalad fluid-shift in the formation of VIIP. VIIP is caused by a prolonged increase in orbital CSF spaces that compress the globes' posterior pole"
This is the number 1 issue for prolonged space flight and it is fair to say IXC will team up with NASA for a trial on the Mars Mission departing in July/August this year.
"Cerebrospinal fluid (CSF) is a physiologic fluid for protecting brain and maintaining intracranial pressure (ICP). It is produced at choroid plexus and a total volume of 140 mL are actively circulating and turned over daily. After severe craniomaxillofacial trauma, the destruction of the meningeal structure may lead to the CSF leak from the subarachnoid space. Post-traumatic CSF leaks are seen 1% to 3% of all closed traumatic brain injuries (TBI) in adults and 80% to 90% of all the causes of CSF leaks in adult patients are due to head injuries.22,28) The risk of meningitis from the traumatic CSF leak can present with high morbidity and even mortality depending on the cause and site of CSF leak."
So IIH is an easy subject to choose to start with as if we can prove that Exanetide can reduce CSF production for IIH it could pave the way for much much bigger areas as mentioned above, IIH is just an easy one to prove up because there are no other drugs in the market!
CSF also can lead to many other problems from doing a quick read.
IXC Price at posting:
$1.03 Sentiment: Buy Disclosure: Held
