stapled peptides v phylomer peptides, page-9

Hi Wayne,

Not sure if you managed to read my reply earlier today but since the past 4 days posts have yet to re-appear on original HC, thought I'd re-post.

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Thanks Wayne, great post.

You may recall I asked these questions a while back in relation to the endosomal escape technology.

If Phylogica are are currently applying the endosomal escape technology in the Roche project, what's to say this isn't being applied in the Janssen program with the second generation customised libraries or the company's in-house libraries?

This could really be a potential game changer to be able to detect which peptides escape from endosomes. I'd say it would have many of our current and prospective partners excited. As you've highlighted in your recent post, the company just needs a little more validation data and more importantly a patent filed before they make a big PR 'splash' about it.

We are not disclosing more data on BEN5000 at this juncture so we can present it at a scientific conference (ie: we want to make a splash), said Woolf, my post February 8, 2013.

I'm wondering whether IBC's Next Generation Protein therapeutics Summit in the US June 26-28 2013, will be the perfect venue for Phylogica to present their exciting endosomal escape technology together with data on the BEN_5000 phylomer?

8:25am - Chairman's Remarks
Paul Watt, Ph.D., CEO, Phylogica Ltd., Australia

4:15pm - Phylomer Libraries as a Rich Source of Peptides Targeting the Intracellular Space

Phylomers are a new class of peptide, derived from fragments of biodiverse microbial genomes. Phylomer libraries can also be used to identify new cell penetrating peptides for delivery of macromolecules and nanoparticles into cells. Some of these cell penetrating Phylomers are specific for particular cell types. Phylomers themselves can be active against intracellular targets in vivo and can be used to discover and validate new targets using protein interference.

Richard Hopkins, Ph.D., Vice President, Research, Phylogica, Ltd., Australia

http://www.ibclifesciences.com/ProteinSummit/agenda.xml

You'll also note that:

The "neurotropic virulence factors" highlighted on that slide that we've discussed over the past few months (slide 43 of the Technical Presentation) is referring to the BEN_1312 and the BEN_0805 Phylomers and as we've also highlighted, they're for endosomes (ie: true cell penetration).

This is certainly exciting work.

Regards,
Tony