"Immune Response The most important clinical concern in using FBS lies in its potential to provoke adverse reactions from bovine xenoproteins or disease from viral or prion contamination following injection of FBS-grown MSCs (8). MSCs have been shown to incorporate FBS proteins, which may lead to an expression of antibodies post-injection (33).….
When children with osteogenesis imperfecta were injected with BM-MSCs, it was found that one of the six patients experienced an immune response against their MSC injection (37). This patient had developed antibodies against FBS with a 150-fold increase in these antibodies after their second injection suggesting that multiple injections can exacerbate immune responses (37)."
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