Nyrada Inc (ASX:NYR) has reported strong results from a collaborative study into traumatic brain injury at the University of Sydney, in which its lead drug candidate NYR-BI03 showed neuroprotective effectiveness.
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Nyrada is working with the Walter Reed Army Institute of Research and the University of New South Wales on the project, which revealed that NYR-BI03 could prevent secondary brain injury following a penetrating traumatic brain injury.
This was confirmed through MRI imaging conducted at the university, which confirmed statistically significant neuroprotection (p = 0.043) for NYR-BI03.
WRAIR – a globally significant military medical research institution that is part of the U.S. Army – provided an established penetrating TBI model involving 28 test animals, which received continuous intravenous infusion of either NYR-BI03 or a vehicle control, over 48 hours.
Chair of the Scientific Advisory Board (SAB) and UNSW Scientia Professor Gary Housley said these results were significant. “This study provides strong evidence that Nyrada’s NYR-BI03 drug protected the brain following severe TBI.”
“This was determined using a new MRI approach for quantifying brain tissue integrity.”
At the same time, Nyrada is progressing NYR-BI03 – a first-in-class TRPC 3/6/7 blocker with a novel mechanism of action – through a Phase I clinical trial to assess its safety and tolerability.
Readouts are expected in the third quarter of the 2025 calendar year.
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