s we approach the 6 month data release in our Synovial study, 008, things at the Mozz camp are slowly heating up...
Tonight a special, admittedly the science is heavy, but I will do my best to make it bite sized pieces for us to digest and so we can eventually complete that subject above....
Symptomatic relief is indeed one thing...tonight, we cover the next step and the potent accelerant that will help us get there...what is this next step, stay tuned!
A two part'er again tonight with a plethora of info just not fitting in the one post. In Part 1 we will cover some necessary definitions and background, we take a closer look at a different part of joint anatomy, one we haven't focused on a lot in the past. Its then in Part 2 that we will draw upon some fairly impressive conclusions...
As always, do now enjoy.
INTRO
OA effects many, by 2040 it is estimated some 78 million Americans will be affected.2
Mate, where are we going with this, there are so many patients right now, imagine by 2040?!
But Paradigmers, I don't just focus on the West, what about the East?
How's this for a stat:3
... the number of artificial hip and knee replacement operations in China exceeded 900 000 in 2019 and is still growing rapidly at a rate of nearly 20% per year, according to the incomplete statistics of Beijing Union Medical College Hospital.
.
So we are acutely aware of how vast this problem is, we certainly need a solution that can address this symptomatically...for example, pain reduction, function improvement....but in tonight's post we go one step further, and its quite a leap of a step...
DEFINITION TIME
Yeah before we get to anything remotely interesting, we need a few definitions out of the way so we are all on the same page!
Intervertebral disc (IVD for short) , these are the cushiony bits (You can tell this is Mozz Speak can't you) between the vertebrae...yeah lets have a look at some pics to make it easy to understand how this stuff hangs together! 3,4
But those two diagrams above while they are good, they aren't enough for Mozz, and aren't enough for you...we need this third one....
What's so good about that third fig?
Let me point it out some more...
Yep, there is cartilage there....
In fact these intervertebral discs are the largest structures in the body that have no vascular supply. Its because of osmosis that each disc absorbs the required nutrients. Now I know why our friend @adherent places so much emphasis on strengthening his core...one of the chief areas is the spine...and it is the contracting action of the muscles and fibres surrounding this region that need to work....squeeze in...squeeze out..to literally feed these amazing structures. Read on to get a sense of our drug's incredible role here.
Ok so we have a better idea of how it all looks, great, a little more on how it functions!
This amazing structure has a number of important features:
Its the spine that connects the skull to the pelvis
It is a major support structure in the axial skeleton
It provides flexibility
It maintains weight bearing properties during flexion-extension of the spine
It allows for twisting/bending movements
We have 23 IVD's in total. The IVD joint itself as the researchers coin it, can be thought of as the following:
The IVD joint is a syndesmosis and dynamic fibrocartilaginous viscoelastic weight-bearing cushion that provides mechanical stability during axial spinal loading and spinal flexibility during bending, flexion, and extension.
Mate, that is one thing about science and the English language, you can get fairly precise in the articulation of what something does and it's function!
Let's break that one quote up a bit more so we get a better sense of what they mean!
SYNDESMOSIS - Immovable joint or path thereof
FIBROCARTLAGINOUS - An elastic material that is comprised of both fibrous tissue and cartilage
VISCOELASTIC - The combo of elastic and viscus properties (Think super heated metal for instance)
AXIAL SPINAL LOADING - A compressive force exerted vertically through the spine
Hmm , I think we all get a sense of how important this bio structure is...and how important it is to STAVE OFF INFLAMMATION......yeah, we are slowly working our way to the magic juice, you can tell I'm building to a crescendo.
But what about a burning question, Does the IVD have a synovium?
The answer is YES.
You reading this should understand the ramifications of this, if you don't, read this article on our 008 program we are currently undertaking:
(Single left click the below hyperlink if you need more info on what 008 is
The amazing article I'm referring to (see Main ref in Part 2) then goes on to state what the IVD is comprised of and some of the involved biology.
They mention things like
The IVD is comprised of intricately organised composite tissue
It has cartilaginous end plates
The cartilage interfaces with bony vertebrae
The Collagen rich fibres encompass regions of the IVD
There is a central PG rich region in the IVD
Why do I mention these regions and anatomies? Because your drug, my drug, influences them all.
As a bit of background before this next quote, NP stands for nucleus pulposus and is the soft gelatinous part in the central portion of the disc.
Just one statement ties all of these above requirements together by the researchers:
The centrally located NP is rich in large space-filling PGs such as aggrecan and versican that form macroaggregate structures with hyaluronan (HA). These aggregates have impressive water regain properties that equip the NP with weight-bearing properties and enable the composite IVD to act as a hydrodynamic viscoelastic biomechanical shock absorber.
I'm not sure If I need to clarify that any more...but mate...
We know iPPS is responsible for an increased proliferation of Prostoglycans (PG above), we know it stimulates HWHA which is responsible for the immense fluidity of these vital tissues. iPPS has a direct consequence on the extra cellular matrix and adds the tensile strength vitally required for these supporting structures. Did someone say Collagen production? It also facilitates Aggrecan.
Again, I can't vouch for you but one day in the (distant?) future I will buy a nice car and let me just explain to you, I want one of those electronic Acceleration Sensitive Dampening type shock absorber units on it...yes indeed its a nice to have...but when it comes to my joints? ....a decent shock absorber isn't just a nice to have....it's a HAVE TO HAVE.
Yeah - I want this quality in and around my synovium, the A8 is and it's incredible shock absorber system is out of my league, but I'll make time and effort for iPPS's influence on our own natural shocks...
So, If I can enhance it naturally via internal stimulation by a naturally based molecule....my hand is raised. I want me some of that, particularly as I get older and my cartilage and surrounding joint pathologies starts to weaken.
The researcher put it this way:
With aging, cumulative repetitive strain injury to these fibrillar structures can damage these collagenous networks and anchorage points. This becomes visible over time as macroscopic changes in tissue morphology, and specific clefts, fissures, and annular rim lesions that are revealed when tissues are examined using microscopy, and when these become advanced, they are also evident macroscopically by naked eye observation. These features compromise the biomechanical competence of the IVD.
Here concludes Part 1.
Part 2 starts off with a bang, a couple of headline statements...then we tackle a little more background before we really start hitting the tarmac hard with what this powerful jet like drug can do for you and in a particular and notable combination! (I'm off to the air show tomorrow after a 10 year hiatus for me hence the jet analogies there).
s we approach the 6 month data release in our Synovial study, 008, things at the Mozz camp are slowly heating up...
Its the spine that connects the skull to the pelvis
It is a major support structure in the axial skeleton
It provides flexibility
It maintains weight bearing properties during flexion-extension of the spine
It allows for twisting/bending movements
(20min delay)