Tamiflu Resistance in Vietnam Increases ConcernsRecombinomics...

Tamiflu Resistance in Vietnam Increases Concerns
Recombinomics Commentary 13:11
August 25, 2009


Experience over 2-3 times the number of days of treatment compared with regular time and had thought at death, two cases can cum A/H1N1 have been heavily doctor Pham Ngoc Thach hospital Savior success.

Previously, patients underwent 12 CTH was immediately treated influenza A/H1N1 ineffective. The VMQ patients still positive for influenza A/H1N1 to 22 days after treatment

However, through the use Ralenza to treatment instead of Tamiflu (flu Ralenza only treatment for severe cases). Latest test results immediately 24/8 that the two patients were negative to H1N1 virus and will discharge in a few days.

The above translation suggests there are multiple cases of Tamiflu resistant H1N1 in Vietnam. Patients treated with Tamiflu failed to respond, even when treated early, but treatment with Relenza produced improvement and elimination of H1N1.

These data follow reports from adjacent Thailand on resistance there, and suggest that resistance is becoming increasingly widespread. The first confirmed case of resistance was in Singapore, where the patient (in May) quickly developed resistance, suggesting H274Y was circulating as a minor population which was not detected in samples collected prior to treatment, but was found in the absence of wild type a few days after the start of treatment.

Similarly, the four confirmed cases in the United States fall into two clusters of two (in immune-compromised patients in Seattle and summer campers in North Carolina), which again suggest resistance is circulating as a minor population which leads to rapid appearance of resistance. Clusters of cases in Texas along the Mexican border have been reported and denied.

Moreover, prophylactic and treatment use of Relenza is appearing at increased frequency in containment recommendations, further supporting the evidence indicating Tamiflu resistance is worldwide and increasing.