Hi Tony, The article Excited about Cycling provides excellent context in relation to the points which you have made about macrocycles;
"Natural macrocycles are chemically complex and difficult to synthesize, which has prevented the large-scale synthesis of compound libraries."
What is the advantage of natural macrocycles?
"The clinical successes of macrocyclic natural products [like the fungal-derived cyclosporine] provide tantalizing hints of what could be achieved by the systematic exploration of this compound class."
What if Phylogica could harness natural products and create large-scale synthetic libraries? Perhaps this is exactly what they have been able to achieve. From the Annual Report for 2013;
"[Efforts include the generation of] genetically encoded macrocyclic phylomer libraries that promise to significantly improve the drug-like properties of hits that emerge from the various screens."
Wayne.
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