Sorry if this has been posted already. MELBOURNE, Australia,...

Sorry if this has been posted already.


MELBOURNE, Australia, Oct. 16, 2024 /PRNewswire/ -- Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) today announces thirteen abstract presentations featuring the Company's ongoing theranostic development, medical technologies (MedTech), and research and innovation (R&I) programs at the 37^th Annual Congress of the European Association of Nuclear Medicine (EANM) to be held in Hamburg from 19 – 23 October 2024.

Telix's extensive theranostic pipeline will be showcased in presentations covering: TLX250-CDx (Zircaix®^[1], ⁸⁹Zr-girentuximab) kidney cancer imaging, including first real-world clinical experience; TLX101 (¹³¹I-iodofalan or ¹³¹I-IPA) glioblastoma therapy; TLX66 (⁹⁰Y-besilesomab) bone marrow conditioning therapy; TLX252 (²²⁵Ac-girentuximab) carbonic anhydrase IX (CAIX)-targeted alpha therapy; and SENSEI®, Lightpoint's robotic-assisted gamma probe.

Dr. David N. Cade, Telix Group Chief Medical Officer, said, "We are pleased to be able to so comprehensively showcase our pipeline at EANM – the largest gathering of nuclear medicine professionals worldwide – with a sponsored symposium, and abstracts accepted across Telix's late-stage theranostic programs in kidney and brain cancers, and in bone marrow conditioning. As in previous years, it is an honour for us to support the EANM Sanjiv Sam Gambhir Young Investigator Award. This is an exciting opportunity for a junior physician or scientist to further develop their career in radiopharmaceuticals, in memory of an extraordinary man and an inspiring educator."

We look forward to seeing delegates at Telix's booth in Hall H, Stand H29 to discuss Telix's industry leading theranostic pipeline in urologic oncology (prostate, kidney and bladder cancers), neuro-oncology (glioma), musculoskeletal oncology (sarcoma) and hematology, our associated medical devices, and opportunities for collaboration.

EANM presentation details are as follows:

Sponsored Symposium: Does size matter in targeted radionuclide therapies?

Chairperson: Professor Viktor Grünwald, University Hospital Essen, Essen, Germany.

• Why size matters: The relative benefits of antibodies vs. small molecules in oncology
  • Prof. Arturo Chiti, IRCCS San Raffaele Hospital, Milan, Italy
• When small may be smart: The role of small molecules in neuro-oncology
  • Prof. Nathalie Albert, Ludwig-Maximilian's-University of Munich, Munich, Germany
• Where big may be best: The power of antibodies in onco-hematology
  • Prof. Stefano Fanti, University of Bologna, Bologna, Italy
• How size will shape the future: The choice between antibodies and small molecules in uro-oncology
  • Prof. Karolien Goffin, University Hospital Leuven, Leuven, Belgium
• Date & Time: Sunday, 20 October, 2024, 13:15 – 14:45 CEST
• Location: Hall G1, Congress Center Hamburg

Abstract presentations

Title: Unravelling radiobiological and immunological mechanisms driving effective CAIX-TRT and ICI combination therapy
Presenter: S. Kleinendorst, RadboudUMC, Netherlands
Date and Time: 20-Oct-24, 08:00 – 09:30
Session: Cutting Edge Science Track - TROP Session: Dosimetry Committee: Preclinic and Radiobiology
Format: Oral
Location: Hall Y4-Y9
Presentation ID: OP-022

Title: Accuracy of personalised single time point dosimetry for bone marrow and liver dosimetry in TLX66 (⁹⁰Y-Anti CD66) radioimmunotherapy
Presenter: A. Nautiyal, University Hospital Southampton, United Kingdom
Date and Time: 20-Oct-24, 15:00 – 16:30
Session: Cutting Edge Science Track - TROP Session: Dosimetry Committee: Dosimetry: A Question of Time
Format: Oral
Location: Hall Y4-Y9
Presentation ID: OP-158

Title: Tumour margin thickness inference for ^99mTc radio-guided surgery using internal conversion electrons
Presenter: J. Moo, Telix
Date and Time: 21-Oct-24, 08:00 – 09:30
Session: Cutting Edge Science Track - TROP Session: Physics Committee: Data Corrections / Image Enhancement
Format: Oral
Location: Hall Y4-Y9
Presentation ID: OP-289

Title: Radiation protection considerations with TLX250-CDx (⁸⁹Zr-girentuximab) PET/CT experience in France
Presenter: C. Morgat, Department of Nuclear Medicine, University Hospital of Bordeaux, France
Date and Time: 21-Oct-24, 15:00 – 16:30
Session: TROP Session: Radiation Protection Committee: Radiation Protection in Diagnostic Imaging Procedures
Format: Oral
Location: Hall Y1-Y3
Presentation ID: OP-452

Title: Correlation of tracer uptake in sentinel lymph nodes as measured on SPECT/CT and during intraoperative gamma tracing with the SENSEI drop in gamma probe: the UZ Leuven experience
Presenter: M. Manley, Nuclear Medicine, University Hospitals Leuven, Belgium
Date and Time: 22-Oct-24, 08:00 – 09:30
Session: Cutting Edge Science Track – TROP Session: Physics Committee: SPECT/CT Quantification
Format: Oral
Location: Hall Y4-Y9
Presentation ID: OP-543

Title: Development of ¹⁶¹Tb-DOTA-HYNIC-panPSMA for targeted radionuclide therapy of prostate Cancer
Presenter: C. Morgat, Department of Nuclear Medicine, University Hospital of Bordeaux, France
Date and Time: 22-Oct-24, 08:00 – 09:30
Session: M2M Track - TROP Session: Radiopharmaceutical Sciences + Translational Molecular Imaging & Therapy Committee: From Radionuclide to Clinical Translation
Format: Oral
Location: Hall X1-X4
Presentation ID: OP-532

Title: Feasibility and tolerability of TLX101 (¹³¹I-IPA) monotherapy in progressive and recurrent high grade gliomas; an ongoing single institution case series
Presenter: N. Tolboom, University Medical Centre Utrecht, Netherlands
Date and Time: 22-Oct-24, 16:45 – 18:15
Session: TROP Session: Neuroimaging Committee: Neuro-Oncology
Format: Oral
Location: Hall Y10-Y12
Presentation ID: OP-758

Title: The emerging role of TLX250-CDx (⁸⁹Zr-girentuximab) PET/CT in accurate characterisation and staging of ccRCC: early experience with three patients
Presenter: F. Gelardi, Università Vita-Salute San Raffaele, Italy
Date and Time: 23-Oct-24, 08:00 – 09:30
Session: TROP Session: Case Report Session 2: You Won't Believe the Things I've Seen!
Format: Oral
Location: Hall Y1-Y3
Presentation ID: OP-824

Title: Development of girentuximab as a theranostic tool in non-renal indications
Presenter: A. Ivashkevich, Telix
Date and Time: 23-Oct-24, 08:00 – 09:30
Session: e-Poster Presentations Session 13: Translational Molecular Imaging & Therapy Committee: Molecular Imaging & Therapy
Format: Oral ePoster
Location: Hall F
Presentation ID: EPS-270

Title: Preclinical evaluation of DNA damage response inhibitors and TLX252 (²²⁵Ac-DOTA-girentuximab) combination therapy
Presenter: Z. Cao, Olivia Newton-John Cancer Research Institute, Australia
Date and Time: 23-Oct-24, 08:00 – 09:30
Session: e-Poster Presentations Session 13: Translational Molecular Imaging & Therapy Committee: Molecular Imaging & Therapy
Format: Oral ePoster
Location: Hall F
Presentation ID: EPS-269

Title: Development of Kit-Composition for the Preparation of ^99mTc-PSMA-GCK01 / RHN001-Dx
Presenter: J. Cardinale, University Hospital Duesseldorf, Germany
Session: D: Technical Studies -> D5 Radiopharmacy/Radiochemistry -> D57 Radiopharmaceutical Preparation and Quality Control
Format: e-Poster
Location: e-Poster Area
Presentation ID: EP-1037

Title: Development of ¹⁸F-labelled lactate for oxidative cancer imaging
Presenter: M. da Silva Morais, Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCLouvain), Belgium
Session: D: Technical Studies -> D5 Radiopharmacy/Radiochemistry -> D55 Radiopharmacokinetics and Drug Development
Format: e-Poster
Location: e-Poster Area
Presentation ID: EP-1010

Title: Radiolabelling DOTA-HYNIC-panPSMA with actinium-225 for in vivo studies
Presenter: K. Attia, Telix
Session: D: Technical Studies -> D5 Radiopharmacy/Radiochemistry -> D53 New Radiopharmaceuticals - Therapy
Format: e-Poster
Location: e-Poster Area
Presentation ID: EP-0985