There is much that troubles me about the Pfizer vaccine...

There is much that troubles me about the Pfizer vaccine announcement and most of it stems from my experience of over 25 years working as a medical laboratory scientist. I fully understand the pressures involved in getting this drug to commercialisation but it concerns me. As far as I can ascertain (no paper has been released) Phase 3 trials have not concluded i.e. efficacy trials ... does it work?

• We don't know what type of clinical trials were conducted (double blind, randomised double blind etc etc)
• We don't know how the vaccine worked. Did it prevent infection with the coronavirus or did it prevent development of symptoms of the disease (Covid-19) How severe were the symptoms?
• How severe were the Covid-19 symptoms in the placebo group?
• We don't know if there were any or what were the side-effects of the vaccine
• We have been told that the vaccine needs to be stored at minus 80deg, I presume this means in liquid nitrogen. How will the logistics of distribution work? Presumably people will have to get themselves to a vaccination centre. How will this work in poorer countries?
• One of the greatest benefits of the Sabin vaccine has been the ease of distribution in poorer countries, the vaccine an be easily transported to remote populations in containers with regular freezer packs. Will it be a case of priority for the vaccine is given to the richer countries with well-established health infrastructure. In the past, children and adults have died from being inoculated with improperly stored vaccines.
• I believe that all the Pfizer trials have been done on adults, will the vaccine be tested on children? When?
• Pfizer is an enormous, reputable Pharma.

Thats all I can think of for now, I'll answer your other question later,

cheers, h