"indicating limited to no efficacy in a murine xenograft model most related to humans from an IV line"
"All of this research combined provides very clear indication that the combination of CF33 with PDL1 has not and does not show efficacy through IV administration."
"I believe the limited IV efficacy will be confirmed in humans"
86% of cholangiocarcinoma patients receiving Vaxinia via IV have no uptake of the active substance by tumors. The drug does not work systemically, which was clearly evident in preclinical models 2 years ago.
Perhaps someone would like to propose what the improvement will be from the addition of IV Vaxinia to standard of care FOLFOX?
(20min delay)