I'm unsure what point you're trying to prove, lengthy posts quoting plenty of references presumably to sound more authoritative?
But the crux of your argument seems to be that IV route will be unsuccessful based on it not already been successfully done, in humans, by others in the past? Despite the promising pre-clinical results achieved in animals / murine models.
Isn't that whole the idea and what the commotion is about, we are soon to see results, safety and efficacy on these 'first in human' trials?
YF has been buzzing on the progress and quoted as saying numerous times now that they are seeing CF33 behave in humans as it has done in animal trials. That's a mic drop moment if you ask me.
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I'm unsure what point you're trying to prove, lengthy posts...
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