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The Clinicians Speak

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    At the risk of being given a stern lecture that I don’t know what a clinical trial, regulatory pathway or statistical analysis is, I thought I might share these lists I have compiled of publications and abstracts reporting on the clinical use of BTM. I promise I haven’t gone cherry picking – if I found it, I included it!

    While many of these titles have been reported at different times on the media thread, I thought it was worthwhile to bring them together in one place on their own thread. This is not only for the purpose of easier reference but also to highlight how there is a growing body of clinical evidence, coming from different clinicians, based in different hospitals in different geographies, supporting the use of BTM in diverse applications in hundreds of patients.

    No particular order has been used. Reference details have been provided where possible. Unfortunately, I couldn’t provide links for some of the abstracts, but in most cases, the presenter name at least is provided.

    Happy reading!

    Novosorb BTM - Clinical Publications

    Biodegradable Temporizing Matrix Reconstruction of Complex Perineal Burn Wound: A Case Report.

    Concannon E, Coghlan P, DamKat Thomas L, Solanki NS, Greenwood JE.J Burn Care Res. 2021 Sep 30;42(5):1038-1042. doi: 10.1093/jbcr/irab073.PMID: 33889942

    Treatment of a Full-Thickness Burn Injury With NovoSorb Biodegradable Temporizing Matrix and RECELL Autologous Skin Cell Suspension: A Case Series.    Three case studies
    Larson KW, Austin CL, Thompson SJ.J Burn Care Res. 2020 Jan 30;41(1):215-219. doi: 10.1093/jbcr/irz179.PMID: 31765469 Free PMC article.

    Lessons Learned From Two Survivors of Greater Than 90% TBSA Full-Thickness Burn Injuries Using NovoSorb Biodegradable Temporizing Matrix and Autologous Skin Cell Suspension, RECELL: A Case Series.
    Malkoc A, Wong DT.J Burn Care Res. 2021 May 7;42(3):577-585. doi: 10.1093/jbcr/iraa176.PMID: 33022032

    A biodegradable polyurethane dermal matrix in reconstruction of free flap donor sites: a pilot study.
    Ten patients
    Wagstaff MJ, Schmitt BJ, Coghlan P, Finkemeyer JP, Caplash Y, Greenwood JE.Eplasty. 2015 Apr 24;15:e13. eCollection 2015.PMID: 25987938 Free PMC article.

    Free Flap Donor Site Reconstruction: A Prospective Case Series Using an Optimized Polyurethane Biodegradable Temporizing Matrix.
    Ten patients
    Wagstaff MJ, Schmitt BJ, Caplash Y, Greenwood JE.Eplasty. 2015 Jun 26;15:e27. eCollection 2015.PMID: 26171099 Free PMC article.

    Reconstruction of Chronic Wounds Secondary to Injectable Drug Use with a Biodegradable Temporizing Matrix.
    Two patients
    Cheng C, Kwiecien GJ, Rowe DJ, Gatherwright JR, Chepla KJ.Plast Reconstr Surg Glob Open. 2021 Jul 12;9(7):e3678. doi: 10.1097/GOX.0000000000003678. eCollection 2021 Jul.PMID: 34262839 Free PMC article.

    Reconstruction of Extensive Calvarial Exposure After Major Burn Injury in 2 Stages Using a Biodegradable Polyurethane Matrix. Case report
    Greenwood JE, Wagstaff MJ, Rooke M, Caplash Y.Eplasty. 2016 May 9;16:e17. eCollection 2016.PMID: 27222681 Free PMC article.

    Reconstruction of an Anterior Cervical Necrotizing Fasciitis Defect Using a Biodegradable Polyurethane Dermal Substitute.   Case report
    Wagstaff MJ, Caplash Y, Greenwood JE.Eplasty. 2017 Jan 25;17:e3. eCollection 2017.PMID: 28197297 Free PMC article.

    Surviving an Extensive Burn Injury Using Advanced Skin Replacement Technologies.
    Case report
    Kelly C, Wallace D, Moulin V, Germain L, Zuccaro J, Galdyn I, Fish JS.J Burn Care Res. 2021 Aug 3:irab146. doi: 10.1093/jbcr/irab146. Online ahead of print.PMID: 34343315

    An Alternative Dermal Template for Reconstruction of Complex Upper Extremity Wounds.
    Six patients
    Wu-Fienberg Y, Wu SS, Gatherwright J, Chepla KJ.Plast Reconstr Surg Glob Open. 2021 Jul 12;9(7):e3674. doi: 10.1097/GOX.0000000000003674. eCollection 2021 Jul.PMID: 34262837 Free PMC article.

    Wound healing and dermal regeneration in severe burn patients treated with NovoSorb® Biodegradable Temporising Matrix: A prospective clinical study.
    Thirty patients
    Lo CH, Brown JN, Dantzer EJG, Maitz PKM, Vandervord JG, Wagstaff MJD, Barker TM, Cleland H.Burns. 2021 Jul 31:S0305-4179(21)00199-6. doi: 10.1016/j.burns.2021.07.014.

    Experience with a synthetic bilayer Biodegradable Temporising Matrix in significant burn injury
    Five patients
    John E.GreenwoodaBradley J.SchmittaMarcus J.D.Wagstaffb https://doi.org/10.1016/j.burnso.2017.08.001


    A consecutive case series of defects reconstructed using NovoSorb Biodegradable Temporising Matrix: Initial experience and early results
    Twenty five patients with a range of defects resulting from acute full thickness burn injury, burn scar revision, necrotising soft-tissue infection, tumour excision and traumatic loss.
    https://www.jprasurg.com/article/S1748-6815(20)30248-5/pdf

    A paradigm shift in practice—the benefits of early active wound temporisation rather than early skin grafting after burn eschar excision
    Article on the evolution of the practice of early wound temporisation at Royal Adelaide Hospital. Paper written after the treatment of 29 patients with major burns.
    https://journals.sagepub.com/doi/10.1177/0310057X19895788


    Pediatric limb salvage after severe thermal injury
    Case report
    https://www.sciencedirect.com/science/article/pii/S2468912220300080


    Successful proof of the ‘two-stage strategy’ for major burn wound repair
    Case report
    https://www.sciencedirect.com/science/article/pii/S2468912220300328#


    Case report: The use of biodegradable temporising matrix in breast reconstruction following flame burn to chest
    https://www.sciencedirect.com/science/article/pii/S2468912220300341


    Use of Biodegradable Temporizing Matrix (BTM) in large trauma induced soft tissue injury: A two stage repair
    Case report
    https://www.sciencedirect.com/science/article/pii/S2213576620302864


    Management of an open nasofrontal encephalocele during the first day of life
    Case report
    https://link.springer.com/article/10.1007/s00381-021-05102-1


    Biodegradable temporising matrix in severe meningococcal septicaemia: a case report
    https://ajops.com/index.php/ajops/article/view/226/457


    Biodegradable Temporizing Matrix Reconstruction of Complex Perineal Burn Wound: A Case Report
    https://academic.oup.com/jbcr/article-abstract/42/5/1038/6247101?redirectedFrom=fulltext


    Experience with NovoSorb® Biodegradable Temporising Matrix in reconstruction of complex wounds
    Twenty seven patients with 35 wounds
    https://pubmed.ncbi.nlm.nih.gov/34085755/


    Expanding into the future: Combining a novel dermal template with distinct variants of autologous cultured skin substitutes in massive burns
    Case report
    https://www.sciencedirect.com/science/article/pii/S2468912221000213


    Sternotomy through anterior chest wall burns temporised with an implanted synthetic dermal matrix
    Case report
    https://www.sciencedirect.com/science/article/pii/S2468912221000250


    Minimalistic reconstruction of exposed skull in a complex craniovertebral polytrauma
    Case report
    https://surgicalneurologyint.com/su...LzCdeEsppmcgu4LRTDjHDqPk1P8SSI45lj56vRv7F-7gY


    Timing of Delamination of Biodegradable Temporizing Matrix Prior to Cultured
    Epidermal Autografting in Burn Reconstruction: A Case Report with
    Literature Review

    https://www.sciencedirect.com/science/article/pii/S2468912221001097


    Non-Invasive and Surgical Modalities for Scar Management: A Clinical Algorithm.
    Discussion of reasons for choice of BTM as preferred dermal regeneration template plus case report   
    JPM | Free Full-Text | Non-Invasive and Surgical Modalities for Scar Management: A Clinical Algorithm | HTML (mdpi.com)


    Biodegradable temporising matrix for necrotising soft tissue infections: a case report
    thttps://ajops.com/index.php/ajops/article/view/72/299



    Biodegradable Temporising Matrix (BTM) for the reconstruction of defects following serial debridement for necrotising fasciitis: A case series
    Report on 7 consecutive cases using BTM in the treatment of necrotising fasciitis
    https://www.sciencedirect.com/science/article/pii/S2468912218300750


    Tissue Engineered Successful Reconstruction of a Complex Traumatized Lower Extremity
    Case report
    https://jocr.co.in/wp/2021/09/10/ti...ion-of-a-complex-traumatized-lower-extremity/

    Neglected cutaneous skin malignancy: A patient with concurrent giant basal cell carcinoma and melanoma
    Case report
    https://onlinelibrary.wiley.com/doi/10.1002/ski2.68


    The morbidity associated with paediatric burn wound escharotomies
    Lisa M. Davenport MBBS (Hons), Leila Cuttle PhD BSC(Hons) GAICD, Craig A. McBride BHB MBChB FRACS, Roy Kimble MBChB, FRCSP, FRACS
    ANZ Journal of SurgeryVolume 91, Issue 10



    Novosorb BTM – Clinical Application (Abstracts)

    Is Biodegradable Temporising Matrix a new-age hero of dermal scaffolds and wound closure? The experience in a quaternary paediatric hospital.

    Biodegradable Temporising Matrix (BTM) for neck contracture release. A case presentation from the nursing perspective

    MolecuLighting up! BTM and the MolecuLight in the management of ataxia telangiectasia. A Case Report


    Journal Plastic and Reconstructive Surgery.

    PR850
    BIODEGRADABLE TEMPORIZING MATRIX – EXPLORING ITS DIVERSITY OF APPLICATIONS
    Austin Health, VIC


    PR877P
    APPLICATION OF BIODEGRADABLE TEMPORIZING MATRIX IN MANAGEMENT OF PYODERMA GANGRENOSUM ULCER
    Wollongong Hospital, NSW


    PR879P
    BIODEGRADABLE TEMPORIZING MATRIX (BTM) APPLICATION IN LOWER LIMB SALVAGE
    Royal North Shore Hospital, NSW


    PR880P
    BIODEGRADABLE TEMPORIZING MATRIX FOR ORBITAL EXENTERATION RECONSTRUCTION
    Launceston General Hospital, TAS


    PR928P
    NECROTISING FASCIITIS RECONSTRUCTION USING BIODEGRADABLE TEMPORIZING MATRIX (BTM): CHANGING THE ART OF GRAFTING
    The Canberra Hospital, ACT

    https://onlinelibrary.wiley.com/doi/10.1111/ans.15850



    PS023P
    ABDOMINAL WALL RECONSTRUCTION IN AN INFANT LIVER TRANSPLANT PATIENT

    PR103P
    PROMISING SCAR RESURFACING TREATMENT WITH THE DERMAL SUBSTITUTE POLYNOVO

    PR106P
    RECONSTRUCTION OF AN EXTENDED FOREQUARTER AMPUTATION DEFECT WITH A FREE ANTEROLATERAL THIGH FLAP, BIODEGRADABLE TEMPORIZING MATRIX, AND STAGED SPLIT SKIN GRAFT

    PR109P
    SECONDARY HEALING OVER BIODEGRADABLE TEMPORIZING MATRIX IN THE UNWELL PATIENT: A CASE PRESENTATION

    https://onlinelibrary.wiley.com/doi/10.1111/ans.16823?af=R


    796 Use of a Synthetic Matrix Instead of Allograft for Temporizing a Major Burn
    https://academic.oup.com/jbcr/article-abstract/41/Supplement_1/S234/5776154?redirectedFrom=fulltext


    Comparison of Biodegradable Temporizing Matrix and Collagen-Chondroitin Silicone Bilayer Dermal Regeneration Substitutes
    https://ovsps.org/conferences/abstract_archive/detail.php?id=1357&yr=-1&p=12


    146 The Use of Biodegradable Temporizing Matrix
    Dr Eduardo Gus, a Plastic and Reconstructive Surgeon at the Victorian Adult Burns Service.
    https://academic.oup.com/jbcr/article-abstract/42/Supplement_1/S96/6206241


    638 Biodegradable Temporizing Matrix in Combination with Wide Meshed Graft and Autologous Spray Cell Suspension (ASCS) Graft Can be Used for Reconstruction of Extensive Necrotizing Infections: A Case Report
    Arkansas Children’s Burn Center, Little Rock, Arkansas.
    https://academic.oup.com/jbcr/article-abstract/42/Supplement_1/S175/6206274?redirectedFrom=fulltext


    Reconstruction of diabetic foot wounds using Novosorb® Biodegradable Temporising Matrix (BTM)
    https://www.diabetesfeetaustralia.org/2021-conference/


    214 - The role of dermal substitutes and facial aesthetic subunits in burn scar resurfacing
    https://isbi2021.navus.io/presentation/78970


    Use of three different variants of autologous cultured skin substitutes in a patient with deep flame burns of 95% TBSA in combination with and without NovoSorb® BTM
    https://isbi2021.navus.io/presentation/78274


    Head and Neck Wound Reconstruction with Biodegradable Temporizing Matrix versus Collagen-Chondroitin Silicone Bilayer Dermal Regeneration Substitutes
    http://meeting.nesps.org/abstracts/2021/30.cgi


    The successful use of Biodegradable Temporising Matrix (BTM) in the reconstruction of all fingers in a full thickness burn in a major burns patient
    http://www.anzbaasm.com/6983


    A Novel Use of Fasciotomy and Biodegradable Temporising Matrix (BTM) in the Setting of Systemic Sclerosis
    http://www.anzbaasm.com/6907


    Comparing Biodegradable Temporizing Matrix and Collagen-Chondroitin Silicone Bilayer Dermal Regeneration Substitutes
    https://meeting.nesps.org/abstracts/2021/81.cgi



    Surviving an Extensive Burn Injury Using Advanced Skin Replacement Technologies
    https://academic.oup.com/jbcr/article-abstract/42/6/1288/6337811?redirectedFrom=fulltext


    Radiotherapy for Wound Treated with BTM: A Case Report and Review of Literature
    https://t.co/47HRaa8CFp?amp=1


    Protracted application of Novosorb Biodegradable Temporizing Matrix – A Case Report and Review of Current Literature (Dr James Briffo)
    http://www.anzbaasm.com/7071


    A single centre experience in the use of ARTISS fibrin sealant under BTM in burns reconstructive surgery  (Dr Francesca Dudas)
    http://www.anzbaasm.com/6973


    Treatment of Hidradenitis with Synthetic Biodegradable Matrix Eliminated Postsurgical Hospitalization


    544 Temporizing Matrix in the Complex Wound: A Retrospective Three-year Review
    Sigrid A Blome-Eberwein, MD, Lydia Bothwell


    New published clinical evidence supporting Novosorb BTM for full thickness wounds (Jake Tanner)


    Retrospective analysis of a single center use of Temporizing Matrix in the complex wound: a retrospective three-year review (Lydia Bothwell, ARNP, Sigrid Blome-Eberwein, MD


    Combining two state-of-the-art surgical techniques for the treatment of deep second degree burns (Sigrid Blome-Eberwein, MD)


    Evolution of BTM Utilization in Burns Care – The Game Changer  (Justine O’Hara)


    Role of synthetic dermal matrix for reconstruction of 55 patients with complex “un-graftable” wound defects (Dr Elizabeth Concannon, Royal Adelaide Hospital)


    The Use of BTM in Reconstructive Surgery in children with difficult conditions. Our first experiences. (Dr. med Mechthild Sinnig, senior physician and Katharina Schriek, Pediatric surgeon, Dept. Paediatric Surgery Auf der Bult Centre for XChildren and Adolescents, Hannover)


    Sealing the deal – using novel technologies to heal difficult wounds in vascular patients (Frank Guerriero)


    Overcoming barriers to wound closure despite vascular compromise by using a novel synthetic dermal matrix  (Chris Delaney)


    A quantitative analysis of scar outcomes following the use of Novosorb Biodegradable Temporizing Matrix (BTM): A Case Report   (Dr Daniel Riciardello)


    Cases: treatment of White Island volcano disaster victims & Australian bushfire survivors
 
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