Hi all,
Our study that may have been underpowered by mixing different types of MND groups such as a Bulbar patient with a huge difference in life expectancy than a normal variant MND.
The below referenced study has identified these points.
"Patients with variable clinical subtypes are often pooled in the same study group, which later leads to significant statistical differences in the observations"."The majority of studies enroll patients regardless of their clinical subtype in the same study group, which confers statistical challenges"."Recent trends suggest that studies should be formulated taking genotypic features into consideration to avoid discrepancies in recognizing the ALS subtypes ".
.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626834/
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I heard this song on the radio this morning and straight away , I thought PAA.
https://youtu.be/QdbLirsZ_4Q?si=apSykdsiUiumB6CZ
Kpax
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