PAR 5.00% 19.0¢ paradigm biopharmaceuticals limited..

The Flex?, page-6

  1. 4,343 Posts.
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    A goods evening to you Mangoman,

    Nah it's not just you, like some over ripened mangoes, some of these HC images tend to go off after some time, I've complained about it numerous times to HC admin to no avail.

    I think this is the table you are referring to:



    https://hotcopper.com.au/data/attachments/6393/6393390-1e0620d671d61baf6f758eda1def7a1f.jpg
    From an uptake point of view we don't need to have only "Drugs works great" kinda feedback.

    Those with a "Little better" will also still generally be happy as their pain and loss of function will usually get worse as OA continues it's destructive path over time.

    The current std is so poor that many will simply try iPPS and again, we only need a small fraction of the OA population for us to have a Blockbuster on our hands. Leave aside all the Pain but NON OA conditions this thing is going to be applied to in the future.

    The other aspect to the above is the incredible PGIC figures we have already achieved in the well controlled double blinded studies . This is the patient's impression of pain and more and more the insurers and authorities are taking it into consideration.

    Here is an example in our 005 and 008 studies where n was only 56 and 15 in the respective active groups:




    To get the below anemic p values when n is so low is amazing.


    005:

    https://hotcopper.com.au/data/attachments/6358/6358203-0bcaa72f87635ac48ce6980c94664779.jpg

    008:

    https://hotcopper.com.au/data/attachments/6358/6358224-1b724d935c3b683f6e310e0748a8e7a2.jpg



    The miniscule p values in such low n numbers means the drug simply works for the patient. This is their impression. What I want to see is what are these sorts of values when n is actually 195.








    DYOR



    Last edited by Mozzarc: 19/08/24
 
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