PAR 1.92% 25.5¢ paradigm biopharmaceuticals limited..

Yes yes I know, the short term looks a tad bit gloomy, we are at...

  1. 4,172 Posts.
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    Yes yes I know, the short term looks a tad bit gloomy, we are at some crazy bottom like prices at the moment...here we are, further along the glorious path, within the P3 and we find ourselves where? Almost at the bottom of the barrel. BUT, we ain't the first to be in this sorta position. For those with steely nerves and a longer term outlook, hang on! (My views).


    https://hotcopper.com.au/data/attachments/3959/3959683-9f389f00884120b162540c94b7faa047.jpg
    How?


    Indulge me for a sec...the stockmarket is not a place for revenge...its a place to ascribe FUTURE value. What are you talking about Mozz...we are so undervalued its crazy and I'm getting worried.

    No...wrong attitude...the reason we are down is at least two fold as far as I can gather....

    A) No one knows us and what we have let alone the science about WHY this thing works and how good it can be in the future. They simply cannot predict JUST how life saving, how beneficial this one drug will be..how much life it will give back and how it'll do it safely and effectively and it will actually last more than just the pathetic few hours of Opioids and NSAIDS.

    It takes effort to understand, it takes footwork to compare...and it takes time to forecast and stay the course. The mass investing market does not know about us and what we have, what it can do.


    B) See A)

    C) Ok, the real second point is that no one has the patience as us. We need years....you reading this....YOU must understand that this will not R%cket in the next month...it will take some time...you need to be patient..this is not the time to sell....remember I do not gain personally by typing this...it is my own views, you listen to me....you don't listen to me..that's your prerogative. I'm telling you what I see. Sure I could be wrong -remember that..but mate, even if I'm totally wrong and there is only a tiny fraction of a chance that this will succeed like the science shows, like the patients voice...it is certainly worth having an exposure and KEEPING THIS EXPOSURE FOR A LONG TERM (not at all advice, DYOR).


    Don't forget, the science has not changed, the drug efficacy is the wonderful same as it always has been, the patients I speak to still sing to the wonderful chorus of pain relief...function improvement, some with regression of the disease and others with better sleep at night...an improvement of life....it is the science that does not lie....lets tonight explore the science some more.




    https://hotcopper.com.au/data/attachments/3959/3959693-2dcb26dafaf1acaaf907d53dbcebaae6.jpgonight a special on Hyaluronan, what is it, where is it, what does it do and indeed, why should we care at all about it - how is it related to us anyway?

    Watch out for some scattered Mozz factoids throughout this post, you may just learn something about this little Hyaluronan Acid (HA) that you didn't know, I sure did.

    Quite a bit of material on this wonder oil...so I'll break it up into two parts...

    PART 1 covers the more basics, The WHAT...THE WHERE and some functions.
    In PART 2 we will start to make this personal, what is the role iPPS plays with this good oil, is there a sneaky by-pass around iPPS that we need to be concerned about? We'll also answer the question; is it just one HA molecule we are talking about?


    As per usual, please enjoy:




    PART 1

    THE WHAT

    What is Hyaluronic Acid? It looks and feels like a gel like substance. Its naturally present throughout our body. It is an essential component surrounding the cells (cell matrix) and is even present within the cells themselves.


    https://hotcopper.com.au/data/attachments/3959/3959712-f22aba99bb41af6b467ada095f6e8e24.jpg



    THE WHERE

    Where does this HA fluid reside?

    Well mainly in the skin...BUT importantly for us, there are many places it can be located.

    • Synovial Fluid - Yes this has real repercussions for us in our 008 study. See the factoid below for an interesting tid-bit regarding the synovium.
    • Skeletal tissues - Of course vital in musculoskeletal structures in terms of OA
    • Heart Valves - Heart failure ramifications
    • The Lungs - think ARDS, think Covid, think COPD and Asthma

    Now we get a sense of just one of these modes of action that PPS is directly and indirectly responsible for, the stimulation and production of HA indeed plays multiple roles in many of our tissues. We'll get to these roles HA plays, soon.


    https://hotcopper.com.au/data/attachments/3960/3960147-b430be3bd3a0abfe01e18cf9f0ca6e8d.jpg




    THE FUNCTIONS

    Now this HA fluid has many many benefits, in truth me just posting one article about it in no way does it justice. My aim here is to show you just how important this fluid is at a higher level. How vital a role it plays in the body and THUS howiPPS plays a role in the upkeep and production of this fluid, before we get to that, lets cover off just how many roles this fluid plays.



    https://hotcopper.com.au/data/attachments/3959/3959740-2b57964b27e7b05fb8d5b9b49dc4501f.jpgHydration

    https://hotcopper.com.au/data/attachments/3959/3959741-2b57964b27e7b05fb8d5b9b49dc4501f.jpgLubrication of the joints

    https://hotcopper.com.au/data/attachments/3959/3959744-2b57964b27e7b05fb8d5b9b49dc4501f.jpgAssists in maintaining a cellular framework through which cells migrate

    https://hotcopper.com.au/data/attachments/3959/3959746-2b57964b27e7b05fb8d5b9b49dc4501f.jpgSynthesis of HA increases during tissue injury and wound healing

    https://hotcopper.com.au/data/attachments/3959/3959747-2b57964b27e7b05fb8d5b9b49dc4501f.jpgHA regulates the activation of inflammatory cells to enhance immune response and the response for injury of fibroblasts and epithelial cells

    https://hotcopper.com.au/data/attachments/3959/3959764-2b57964b27e7b05fb8d5b9b49dc4501f.jpgProvides the framework for blood vessel formation (See also Note 1 - Part 2)


    Each and every bullet point above is a post worth writing on.Each and every point above is just a small part of the magic of our drug.Don't forget, the marvellous assistance of HA aided by YOUR iPPS is just ONE aspect of the suite of mechanisms of action that address OA and inflammatory related conditions.



    We will cover the note above in Part 2. Its also in Part 2 where we get down to the nitty gritty, for example, how does the drug YOU have invested in, help HA achieve it's job? We'll also take a sneak peek at a particular network and look out for a few more interesting facts involving HA.
 
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