http://seekingalpha.com/article/3266485-sunshine-heart-c-pulse-th...

http://seekingalpha.com/article/326...-lance-armstrong-effect-setting-c-pulse-apart

Summary

• The onset of the progressive disease, heart failure (HF), starts with an insult of some form or other to the heart.
• Such insult leads to activation of the sympathetic nervous system (SNS), which in turn leads to a cascade of events causing further insults to the heart, a “vicious cycle”.
• Current optimal medical therapy (OMT) only slows the progression of this “vicious cycle”, and in fact, OMT can cause further insult to the heart by forcing it to work harder.
• Sunshine Heart C-Pulse therapy has modes of action that address the curtailment of the “vicious cycle” of progressive HF, while at the same time reducing the workload of the heart.
• What really sets C-Pulse apart from drug therapy is C-Pulse’s ability to increase perfusion of the heart muscle with oxygen rich blood, what I have termed “the Lance Armstrong Effect”.

The Investment Case - An Alpha Opportunity

1. Sunshine Heart is currently undervalued - The current market valuation of $73M is miniscule compared to a potential future value in the $billions, based on meeting an unmet need in a target market in the tens of billions.
2. The C-Pulse path to commercial approval is largely de-risked - The progression to FDA PMA approval is largely de-risked from a technology efficacy and safety point of view. While rate of enrollments of patients in the Pivotal Trial remains a concern, this is a timing issue only and does not put successful completion of the trial at risk.
3. The C-Pulse represents a "Paradigm Shift" in HF treatment - Despite major improvements in the treatment of virtually all cardiac disorders, heart failure (HF) is an exception, in that its prevalence is rising, and only small prolongations in survival are occurring. Sunshine Heart C-Pulse has demonstrated the ability to bring a paradigm shift to HF treatment.
4. The Lance Armstrong Effect - Rests and repairs the heart muscle and improves the performance and stamina of a failing heart.
5. The immediate improvement felt by C-Pulse patients after implant
6. "Promising new therapies" fail while C-Pulse superior efficacy goes largely unrecognized - Despite showing great efficacy in trials, Sunshine Heart has so far not had the publicity accorded to various "promising new therapies" that have not lived up to their hype. This lack of recognition of C-Pulse has created opportunity for savvy investors.