This image should hopefully explain why we think FTO is such a blockbuster opportunity. This image is from a review on m6A RNA methylation and cancer [1]. The larger pink circles I added are where FTO has been shown to have an important role in cancer after the review was written. I know of no more exciting opportunity given we have a clinically ready potent inhibitor of FTO in Bisantrene.
1. Gu, C., Shi, X., Dai, C., Shen, F., Rocco, G., Chen, J., et al. (2020). RNA m6A modification in cancers: molecular mechanisms and potential clinical applications. http://doi.org/10.1016/j.xinn.2020.100066
This image should hopefully explain why we think FTO is such a...
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