I am assuming that when they talk about systemic injection now they are talking about directly into eye and not into the blood so it finds its way to the eye.
Andrew, they are using intravitreal administration into the eye, as opposed to the subretinal surgery required for a gene therapy approach.
The following presentation provides more information on the intravitreal approach as well as a comparison between the two delivery methods – specifically, Slides 18 and 22-25.
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(20min delay)