Basically it's a heterogenous substance that cannot be degraded by cellular machinery. It accumulates throughout life.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235942/
Similar aggregates occur in other tissues. One such example retinal cells that cause macular degeneration.
http://www.ncbi.nlm.nih.gov/pubmed/14604266
therapy for parkinsons clears hurdle, page-13
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