Thanks for the link to the detailed publication - great news for...

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Caerus888

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14/05/21

10:03

Post #: 53170694
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Originally posted by Dubbo66: ↑

This paper just appeared on TBI detection - a good review and introduction to TBI. The last paragraph is below. The competition should be nervous - NanoDx seems likely to meet the "ideal" detector outlined in Table 2 if the covid solution is similar to the TBI performance.

A big step toward the first US commercial POC diagnostic test for mTBI was made by Abbott Diagnostics, recently. Following a non-exclusive license agreement with Banyan Biomarkers in 2019, Abbott received FDA 510(k) clearance for the first rapid handheld blood test for concussions in January 2021. The test runs on the i-STAT™ Alinity™ POC device and it measures amperometrically the UCH-L1 and GFAP biomarkers. The UCH-L1 biomarker complements GFAP as each result is produced by a different type of cell and measures distinctive molecular events.208 The results are given 15 min after the plasma sample is inserted in the cartridge. Building on this initial clearance, Abbott is also working on a test that would use whole blood on i-STAT device.209 Further developments, optimization and additional prospective studies are required to assure sufficient diagnostic specificity and sensitivity in evaluating concussions in patients with mTBI (i.e. multiplex panel extension with additional biomarkers or biomarker types like inflammation proteins and brain damage proteins). As other companies, such as NanoDx™210 that uses an ultrasensitive nanowire technology to resistively measure the biomarkers S100β and GFAP, are following on Abbott's heels, electrochemical POC sensing of blood proteins for mTBI may at last experience a much needed push forward.

https://pubs.rsc.org/en/Content/ArticleLanding/2021/RA/D1RA00589H?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2Fra+%28RSC+-+RSC+Adv.+latest+articles%29#!divAbstract

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Thanks for the link to the detailed publication - great news for TBI / Concussions worldwide - this is really needed in the sporting (& military too) space to determine when participants/players should be sidelined for the brain to recover.

Would be nice to give people the opportunities to try and prevent CTE (Chronic traumatic encephalopathy) - and CTE unfortunately to date still only can be determined post mortem.

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0 Great analysis

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