The NOXCOVID Phase I trial is likely to proceed at warp speed.
- Let’s say the first dose is 1200 mg per day – known to be safe. Cytokine measurement presumably taken every day, so perhaps five days to determine whether 1200 mg NOX66 reduces cytokine levels by a significant amount.
- If a better response is needed, increase the daily dose of NOX66 to say 2400mg.
- If necessary, increase the dose to 3600 mg per day
- Do this in parallel in six hospitals, with say two patients at a time on the same dose, and complete cytokine data for 36 patients could be known within 15 treatment days
- Allow a factor of safety of 100%, so one perhaps one month in all.
I read recently that in the COVID environment, trial results can be released before they go through a peer-review process. The price action today suggests to me that investors don’t want to be left behind if results are released sooner rather than later.
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