to ymav4294: ct scan frequency and pfs results

To yamv4294,

With your experience, what are your thoughts on CT scan frequency and accuracy of the PFS outputs to make conclusions on efficiency?

CANVAS trial patients have CT scan every 2 months (don’t remember about CAN-003), based on the trial time frames and average PFS I don’t expect the difference btw OSC and CVac arms to be more than 3 months max.
So with these numbers in mind the CT scans (every 2 months only) may have a skewing impact on the accuracy of NED.

I guess on average it should follow the Poisson distribution and not affect the large samples (i.e. CANVAS trial), but small samples (CAN-003) may skew to any side.