The biggest one for many is the esteemed 3rd party oncology research companies - running trials literally for years now - and at the cost of their own resources and treasure.
These companies have no obligation to our shareholders or our current or former management they are simply following the science for their specific indication of focus yet they continue to pursue these studies - when they could stop and focus elsewhere.
where there smoke there’s fire - it’s virtually a numbers game with this many individually run trials some running over data delivery dates (which is uncontrollable and a very very good thing - people living longer is what it’s all for).