Apart from needing to have a low conversion of Anagrelide to its active metabolite a lower administered dose may still result in same systemic exposure and subsequent adverse effects.Example: https://www.sciencedirect.com/science/article/pii/S0011393X19300013
Of the942 patients treated with AGRYLIN, 161 (17%) were discontinued from the studybecause of adverse reactions or abnormal laboratory test results. The mostcommon adverse reactions resulting in treatment discontinuation were headache,diarrhea, edema, palpitations, and abdominal pain.
https://www.rxlist.com/agrylin-side-effects-drug-center.htm#consumer
Also see 3.7 Routes of Administration
Apart from needing to have a low conversion of Anagrelide to its...
Add ALA (ASX) to my watchlist
 (20min delay)
|
|||||
|
Last
13.0¢ |
Change
0.010(8.33%) |
Mkt cap ! $136.5M | |||
| Open | High | Low | Value | Volume |
| 12.5¢ | 13.0¢ | 12.0¢ | $133.5K | 1.063M |
Buyers (Bids)
| No. | Vol. | Price($) |
|---|---|---|
| 1 | 11996 | 12.5¢ |
Sellers (Offers)
| Price($) | Vol. | No. |
|---|---|---|
| 13.0¢ | 367267 | 9 |
View Market Depth
| Last trade - 16.10pm 03/05/2024 (20 minute delay) ? |
|
|||||
|
Last
12.8¢ |
Change
0.010 ( 6.25 %) |
||||
| Open | High | Low | Volume | ||
| 12.5¢ | 13.0¢ | 12.5¢ | 582454 | ||
| Last updated 14.53pm 03/05/2024 ? | |||||
| ALA (ASX) Chart |