Nice one...
Good to see an increase in number of Biomarkers to be observed, namely (but not necessarily limited to):
- COMP
- C terminal telopeptide (CTX) -II
- NGF, interleukin (IL) -1ß,
- TNFa,
- IL-6
- A disintegrin and metalloproteinase with thrombospondin motif 5 (ADAMTS-5),
- ARGS (aggrecan cleavage fragments)
- Tissue inhibitor matrix metalloproteinase 1 (TIMP-1)
- CTX-I
- Type II collagen (C2C)
Quite a comprehensive study also looking at Pain, Function and Stiffness along with Serum samples.
Will be illustrative to get a comparison between Synovium and Serum activity and the effects of iPPS on each.
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