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  1. Sam_123
    309 Posts.
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    06/10/20
    15:02
    Post #: 47885625

    President Trump Should Consider Stem Cell Therapy for His COVID-19


    https://www.painnewsnetwork.org/stories/2020/10/4/president-trump-should-consider-stem-cell-therapy-for-covid-19

    President Trump remains hospitalized at Walter Reed Medical Center after being diagnosed with COVID-19 last week, along with First Lady Melania Trump. The president suffered from fever, congestion and fatigue, and received before being admitted Friday.

    Details about his current condition and treatment are scant, but Trump has reportedly received In Saturday night, the president said he was “starting to feel good” but the next few days would be “the real test.”

    With few effective treatments available for coronavirus, the president and his doctors should seriously consider stem cell therapy, which is being investigated in Other experimental therapies like , and are not effective for all patients.

    Coincidentally, President Trump has long been an advocate for stem cell therapy. In his , he acknowledged the medical plight of a woman who was forced to travel to Mexico to use her own stem cells to treat her systemic idiopathic juvenile arthritis. Trump said seriously ill patients “should have access to experimental treatments” without traveling overseas and urged Congress to pass the so that Americans can get help “right here at home.”

    Stem cell therapy may be the safest and most effective treatment for the most life-threatening symptom of COVID-19, acute respiratory distress syndrome (ARDS), an inflammatory “cytokine storm” in the lungs that makes breathing difficult. The conventional intervention for ARDS – mechanical ventilation – is invasive, and can increase the likelihood of .

    Stem cells have intrinsic immune supporting properties that can ease the deleterious effects of ARDS. They could also potentially heal any tissue damage that ARDS may cause to lungs.

    Research Supports Stem Cells for COVID-19

    Even if President Trump’s symptoms are mild, the prophylactic use of stem cells to prevent disease spread is worthy of investigation. is currently conducting a Phase 2 multi-center, double-blind, randomized, placebo-controlled trial to evaluate the prophylactic effectiveness of autologous, adipose-derived mesenchymal stromal cells (MSC).

    of the scientific literature on MSC therapy concluded that “Cellular based therapies hold great promise for the treatment of COVID-19.” echoed that finding, saying “MSCs possess both regenerative and immunomodulatory properties, the latter of which can be harnessed to reduce the severity and longevity of ARDS in patients under intensive care due to SARS-CoV-2 infection.”

    have called MSC therapy a “promising strategy” for COVID-19, but cautioned that “there is not enough clinical evidence to prove the effectiveness of MSCs in the treatment of ARDS.” They called for large-scale, multicenter trials to further explore the safety and efficacy of MSCs.

    Other recent studies have concluded that stem cells for COVID-19 and

    FDA Approved Trials

    Early in the pandemic, the FDA approved several of stem cells for treating COVID-19. These trials are now at various stages of progress, ranging from investigational new drug (IND) applications, to active recruitment of patients, to late stage clinical studies. Trial sponsors include: , , , , , , , , , , , , and .

    More recently, had its IND application approved for umbilical cord-derived MSC cells and ’ IND application for intravenous allogeneic MSCs. The FDA has even cleared existing stem cell product for treating ARDS, allowing the company to treat up to 100 severely affected COVID-19 patients outside of a clinical trial.

    There are also several ongoing international trials of stem cells, including studies in , , , and .

    President Trump and First Lady Melania owe it to themselves – and to us – to consider every possible treatment for COVID-19. The administration should also ensure that all Americans have access to stem cell therapy for COVID-19, by expediting clinical trials, expanding compassionate use, and granting emergency use authorization for advanced stem cell products, as was done for . Ultimately, the president and FDA should relax restrictions on the use of our own stem cells for indications beyond COVID-19.

    We all wish the President and First Lady a full and speedy recovery.

    A. Rahman Ford, PhD, is a lawyer and research professional. He is a graduate of Rutgers University and the Howard University School of Law, where he served as Editor-in-Chief of the Howard Law Journal. Rahman lives with chronic inflammation in his digestive tract and is unable to eat solid food. He has received in China.

    Last edited by Sam_123: 06/10/20
    MSB Price at posting: $3.48 Sentiment: Buy Disclosure: Held
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