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Tumor Immune Microenvironment of Brain Metastases: Toward Unlocking Antitumor Immunity

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    CANCER DISCOVERY
    Absract - aacrjournals.
    Tumor Immune Microenvironment of Brain Metastases: Toward Unlocking Antitumor Immunity
    Matthew R. Strickland ; Christopher Alvarez-Breckenridge ; Justin F. Gainor; Priscilla K. Brastianos
    Review - April 08 2022

    "Figure 5.  Role of microglia and bone marrow–derived macrophages in BrM..

    6. BrM have been shown to have enriched PI3K signaling activity and that PI3K is a master regulator of
    metastasis-promoting microglia/macrophages. PI3K is an attractive therapeutic target with a growing list of CNS-penetrant inhibitors available such as GDC-0084".

    https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-21-0976/694321/Tumor-Immune-Microenvironment-of-Brain-Metastases#.YlKuYdo4cDU.twitter

    Data news from Priscilla K. Brastianos regarding paxalisib (GDC-0084) has been limited for some time.
    Open the link and download the PDF for full details of the abstract.

    Note: Initial interim data from paxalisib phase II brain metastases study with Alliance for Clinical Trials in Oncology 1H CY2022

    Regards.
 
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