May 22 - 25, 2011 TIDES - Oligonucleotide & Peptide Research, Technology & Product Development Hynes Convention Center and Sheraton Boston Hotel - Boston, MA
Boehringer Ingelheim / Bristol Myers Squibb / DAIICHISANKYO Eli Lilly and Co. / Genentech / Genzyme / GlaxoSmithKline Merck / AstraZeneca / Mediimune / NexiGen / Novartis / Pfizer / Roche / Sanofi Aventis / Takeda / and many more
PYC features ----
Creative Peptide Discovery, Selection and Design
1:50 Chairpersons Remarks - Paul Watt, Ph.D., CEO, Phylogica Ltd., Australia
2:00 Peptide and Scaffold Discovery Using CIS Display CIS display is an acellular in vitro display technology that is capable of displaying very large libraries (>10^13) of polypeptides. Its integration with next generation sequencing provides a powerful tool for the mining of small peptide libraries for a variety of applications. We will present data from this platform and also include an engineering study of a small, synthesizable protein domain as a potential therapeutic and a brief overview of our work with cell penetrating peptides. Chris Ullman, Ph.D., Chief Scientific Officer, Isogenica Ltd.,United Kingdom
4:30 - Beyond TAT: Exploring Natural Protein-Derived Phylomer Peptides for Cell Penetration
Phylomer libraries represent a rich source from which to discover new cell penetrating peptides and bioactive cargoes, particularly since several Phylomers have been discovered which are active against intracellular targets in animal models which will be presented. In collaboration with Roche, Phylogica has been screening its Phylomer libraries in order to discover new classes of cell penetrating peptides. This research has yielded a number of distinct structural families of CPPs, some of which may be functioning by a variety of mechanisms. The development of screening approaches for the discovery of cell penetrating peptides will be described together with useful bioinformatic implications of deriving CPPs from natural protein fragments. Paul Watt, Ph.D., CEO, Phylogica Ltd., Australia
"The Industry's Only Event for Full Coverage of the Oligonucleotide and Peptide Markets"
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6.5¢ Sentiment: None Disclosure: Held
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