Rereading some old data how can you not like thisOf these six...

Rereading some old data how can you not like this

Of these six patients treated with PAT-SM6, two have shown stable disease. The first of these (from the 2nd cohort) was a 73 year-old man who had previously received six lines of therapy including a stem cell transplant. At the time of entry into the trial he was resistant to all-available therapies and had rapidly advancing disease. At day +36 after treatment with four doses of PAT-SM6, he showed evidence of stable disease according to the International Myeloma Working Group criteria.

The second responder was a 75 year-old man (from the 3rd cohort) who had previously received four lines of therapy and showed significant progression of his disease. Like the first responder, he showed evidence of stable disease after treatment with PAT-SM6 and currently (now day +82 post treatment) his disease remains stable and he has not gone on to receive any other treatment.

Post inclusion in the trial, five out of six patients went on to receive additional chemotherapy due to advancing disease. Interestingly, two out of those five patients responded very positively to drugs that they had previously been resistant to. This suggests that PAT-SM6 is having a positive influence on the cancer cells by converting them from resistant to sensitive. Overall, there was a median time to next therapy of 42 days and this is certainly considered to be clinically significant.

"Our trial with PAT-SM6 is producing some very exciting data and it is particularly encouraging to see two patients, with end-stage multiple myeloma, respond so positively to treatment with this novel antibody," commented Patrys' CEO, Dr. Marie Roskrow. "All of the patients being recruited into this trial are resistant to the currently marketed drugs and PAT-SM6 is inducing strong and sustained immunological responses."

"As we move into the final cohort of this trial, Patrys is beginning to attract the attention of potential new investors and commercial partners. We are delighted with the progress of the trial and are most grateful to Dr. Rasche and his colleagues for their continuing clinical support," Dr. Roskrow said.

http://www.medicalnewstoday.com/releases/264774.php


Starting to attract the attention of potential new investors and commercial partners. This was in august maybe something to do with the action this week