Thanks LP a great exposition of the components of pharmacokinetics and the more critical pharmacodynamics of drug action. Even with all this wonderful science the more critical issue remains the clinical action on disease in humans. These early double blind trials will go some way to answering a few all important questions but good studies are difficult to undertake, necessitating many precise measures of behaviour and function, with monitored supervision and very compliant subjects. A burden for all and very costly to boot. We'll know all in year!
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