view of retired 747 pilot on mh 370, page-9

"The aircraft depressurised but continued to fly ?

It’s possible. This would explain the initial change in altitude and heading, as well as subsequent lack of communication but not why the ACARS and transponder were turned off."

This seems the sanest scenario, BUT if all were incapacitated, someone must have preset all those course changes and the final flight path into the flight director, which also doesnt gel. Remember, it was reportedly navigating waypoint to waypoint at one stage.....so someone with navigational skills was manually flying OR the waypoints and final flightpath had been pre-entered. There is no third option.

GZ