I think we each should search within for the tranquility of patience. This may take a while yet. Given that what was a funny sounding chemical in a test tube 4 years ago, is now a largely de-risked candidate as a product of commercial and medical significance, the (commercial) value of which should materialise this year is grounds for holding a certain serenity. The biggest risk I see for myself as a long-term holder is my own impatience. Of course I want to see FDA approval and commercialisation next week! oh give me strength - next month!, but wanting it ain't gunna make it so.
And if I can throw in a personal note, I happen to be in a tighter spot financially these last months than I have been for some years, so if you've got any tranquility pills to spare, I may need them yet!