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W.H.O. confirms that cheap steroids reduce Covid deaths 36%, page-44

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kervio

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03/09/20

13:59

Post #: 47058246
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Originally posted by bedger: ↑

You get it on every thread mate. Should you want to discuss anything objectively you often get shut down as a ramper. The results are somewhat of a vindication for dexamethasone. Not unexpected personally, but perhaps a surprise to the market (personally didn't know when they would hit). For those who are interested in competition (and as a treatment for COVID related ARDS it has to be considered that):

RESULTS A total of 299 patients (mean [SD] age, 61 [14] years; 37% women) were enrolled
and all completed follow-up. Patients randomized to the dexamethasone group had a mean
6.6 ventilator-free days (95% CI, 5.0-8.2) during the first 28 days vs 4.0 ventilator-free days
(95% CI, 2.9-5.4) in the standard care group (difference, 2.26; 95% CI, 0.2-4.38; P = .04). At
7 days, patients in the dexamethasone group had a mean SOFA score of 6.1 (95% CI, 5.5-6.7)
vs 7.5 (95% CI, 6.9-8.1) in the standard care group (difference, −1.16; 95% CI, −1.94 to −0.38;
P = .004). There was no significant difference in the prespecified secondary outcomes of
all-cause mortality at 28 days, ICU-free days during the first 28 days, mechanical ventilation
duration at 28 days, or the 6-point ordinal scale at 15 days. Thirty-three patients (21.9%) in
the dexamethasone group vs 43 (29.1%) in the standard care group experienced secondary
infections, 47 (31.1%) vs 42 (28.3%) needed insulin for glucose control, and 5 (3.3%) vs 9
(6.1%) experienced other serious adverse events.

For me I am a little confused as why mortality wouldn't be the primary end-point. I suppose the trial is more about assisting ventilation in moderate to severe patients, a commendable endeavour. There is no significant difference on all-cause mortality. Can you post the one you are referring to?

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I hadn't seen those figures, very surprised that there's no significant difference in all-cause mortality based on what the article was saying. Thanks for supplying them.

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