Matt, I wouldn't say that mgmt comms are tighter (I can't speak for others) but I would say that the power or attraction of being given a green light from the FDA to enter Phase III will greatly outweigh a small (in the grand scheme of things) miss in readouts timeline.
I would say that I have underappreciated the work that goes into a thorough filing and am now understanding that the work now, could save PAR added work later... No doubt someone, somewhere will be disappointed with something that happens, but I suspect the company is in a much better place now the filing has been made.
We just submitted an IND - So now what?, page-24
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