The Phase 1b stage of the ACCENT trial was designed to test ascending doses of orally-dosed narmafotinib in patients, in combination with the standard-of -care chemotherapy regime of gemcitabine combined with Abraxane. This dose-escalation stage has identified a dose of narmafotinib that provides sufficient circulating drug levels to significantly block the activity of the FAK enzyme. Importantly, this dose has been shown to be safe and well-tolerated across the three cohorts of patients (14 in total) in the trial.
And It does not appear that this "Well-tolerance" has changed during Phase IIA
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