When things go right!!!, page-85

You gotta know when to cut losses or at least stem the bleeding (stop buying more). C pulse's most impressive clinical results (weaning and the 6minute walk test improvement) weren't as straight forward as thought.

6minute walk only improved because they started doing multiple sessions a week of physio to specifically train for the test after the 3 month mark. If you took a placebo group who had even half decent medical management I'm sure I could improve their 6 minute walk test (I'm a physio by trade). By no means am I saying that c pulse didn't help, as it would've enabled the patients to cope with the physio a little better... But with c pulse in isolation the six mi ute walk test didn't actually improve.

In terms of weaning, most weaning was being done due to poor compliance or due to other morbidity. While the data was good for one of the patients, the term 'super-responder' for a sick man with cancer was probably a bit rich. Again, to me shows efficacy but doesn't mean this specific device was a world beater.

Too much money was blown away bothering with c pulse one. They could've taken that 40 million they had for the trial and pumped all of that into c pulse 2.

With these solid, but moderate, clinical results, a fully implantable would be a world beater. From a patient point of view, an LVAD or this makes no difference as the cord is just too big a bridge to cross.

The fact they didn't put more money into c pulse two and push it hard think they were blowing smoke up our collective asses about how close c pulse2 actually was to commercialisation.