Share
2,162 Posts.
lightbulb Created with Sketch. 15
clock Created with Sketch.
19/06/16
04:54
Share
Originally posted by septa
↑
You gotta know when to cut losses or at least stem the bleeding (stop buying more). C pulse's most impressive clinical results (weaning and the 6minute walk test improvement) weren't as straight forward as thought.
6minute walk only improved because they started doing multiple sessions a week of physio to specifically train for the test after the 3 month mark. If you took a placebo group who had even half decent medical management I'm sure I could improve their 6 minute walk test (I'm a physio by trade). By no means am I saying that c pulse didn't help, as it would've enabled the patients to cope with the physio a little better... But with c pulse in isolation the six mi ute walk test didn't actually improve.
In terms of weaning, most weaning was being done due to poor compliance or due to other morbidity. While the data was good for one of the patients, the term 'super-responder' for a sick man with cancer was probably a bit rich. Again, to me shows efficacy but doesn't mean this specific device was a world beater.
Too much money was blown away bothering with c pulse one. They could've taken that 40 million they had for the trial and pumped all of that into c pulse 2.
With these solid, but moderate, clinical results, a fully implantable would be a world beater. From a patient point of view, an LVAD or this makes no difference as the cord is just too big a bridge to cross.
The fact they didn't put more money into c pulse two and push it hard think they were blowing smoke up our collective asses about how close c pulse2 actually was to commercialisation.
Expand
I Agree with you but as usual there's a murkier aspect to this, exercising HF patients has been trialed , there wouldn't be a C-Pulse if it worked. Back to overloading an already overloaded heart in a poorly functioning circulatory system doesn't work. You could think that these patients are able to exercise and improve due to a placebo effect however the totality of the data says significant changes are happening and the on off data is futher confirming this and giving a reason for the changes.
Therapy delivery system problem???
Last edited by
xc_mse :
19/06/16