Well you have sparked my interest Jemma. I've been looking for some of Maxineamillion's posts on what really happened at Pfizer but failed to find the relevant ones. She is the definite go to on that. She will have to (again) help out here..... Please Maxine.
I would suggest you read some of Maxine's early posts from 2010/11 and 12.
Have you researched what Gradalis have done?
Have you researched what the City of Hope have done?
Calimmune?
The Haemophilia trial?
Seen Mick Graham's story about his blue rose and the worms and the rat fur?
Safety and efficacy have been shown in many humans without any side effects. You will find this through what the CoH did and Gradalis and Calimmune and others.
If not we can provide links to many interesting reads about the effect and lack of side effect of ddRNAi and the use of viral vectors.
Here is an important paper very relevant to your questions.
http://www.nature.com/mt/journal/v20/n9/full/mt2012119a.html
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