Hi WayneI agree that It is true that Herceptin works better in...

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Few Pennies

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01/12/19

20:42

Post #: 41737497
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Originally posted by waynesworld: ↑

There has been some discussion about the effectiveness of HER-Vaxx in combination with SOC chemotherapy. It is certainly true that chemotherapy in killing the cancer compromises the immune system. The inference is that the study itself is compromised in that the efficacy of HER-Vaxx will be masked by the damaging effect of the chemotherapy. If this were true I doubt whether Herceptin would ever have been approved given that HER-Vaxx and Herceptin target the same receptors.

How to make sense of it. The countervailing effect of the chemotherapy is taken into account in reading the data. The investigators will interrogate the data for evidence of safety and tolerability, proof in regards to the mechanism of action as well testing the hypothesis that administration of IMU-131 in addition to chemotherapy will prolong survival and may delay tumor progression and/or reduce tumor burden in patients.Indeed, Imugene may establish in later studies that HER-Vaxx may work better without combination with chemotherapy. What has been established is that in breast cancer pre-clinical studies, the combination with Herceptin shows significantly higher inhibition than Herceptin alone. Many thanks for the discussion around this point.

The scientific community will know how to connect the dots and Imugene will helpfully direct their analysis. HER-Vaxx could well generate the capital required to progress later trials involving CF33. Imugene can't keep it all inhouse but it would be wonderful to have the opportunity to progress at least one candidate through to drug approval.

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Hi Wayne
I agree that It is true that Herceptin works better in combination with chemo, and I also agree with you that Herr Vaxx targets the same recepter, however the Herceptin antibodies are made / manufactured outside of the human body and not anywhere near chemo when it is made, therefore the DNA of the herceptin antibodies ( T Cells ) cannot be mutated the T cells are formed away from the presence of any chemo, ie Herceptin enters the body with DNA in all the right places and all guns blazing,

In comparison Her Vaxx sets up its factory in the body and starts producing T cells in the presence of the chemo, this results in the T cells produced in this chemo soup actually being made with their DNA mutated,

so no not the same as Herceptin because we are comparing non mutated DNA T cells ( Herceptin) with mutated DNA T cells ( Her Vaxx)

read more about this from the Journal of Immunology
cut and paste this into your browser: www.jimmunol.org/content/190/12/6259.long

fp

Last edited by Few Pennies: 01/12/19

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