https://www.withpower.com/trial/phase-1-solid-tumors-advanced-solid-tumors-3-2022-824fd#safety
rDuration: Up to 2 years from first dosage of study drug
Day 21 to evaluate infection of tumors with CF33-hNIS
Day 30 Frequency ans severity of Adverse Events of IV and IT CF33-hNIS as a monotherapy or in combination with pembrolizumab
Day 42 Recommended Phase 2 Dose (RP2D) of CF33-hNIS as a monotherapy or in combination with pembrolizumab
Year 2 Disease control rate, Duration of response, objective Response rate, overall survival of CF33-hNIS administered as a monotherapy/combo Progression free survival
Evaluate viral titers
Evaluate antiviral immune activation
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