Why IMU is a multi multi bagger, page-426

This is from the CF33 Introduction presented at AACR.

Oncolytic viruses (OVs) are therapeutic agents that have potent, cancer cell-specific antitumor activity, and can be used for targeted gene delivery. We have previously demonstrated that unmodified CF33 is safe, well-tolerated, and effectively kills pancreas cancer at doses of several magnitudes lower than other OVs currently under investigation. We engineered, CF33-hNIS- antiPDL1, on the backbone of CF33, a unique chimeric orthopoxvirus, which shows robust preclinical activity against many solid tumors and inherent strong anti-cancer activity against pancreatic ductal adenocarcinoma (PDAC). We investigated CF33-hNIS-antiPDL1 for its ability to track and kill distant peritoneal metastases after local virus administration in vivo. We show that subcutaneous intratumoral (SC.IT) delivery of CF33-hNIS-antiPDL1 decreases peritoneal tumor burden and improves survival in a PDAC mouse model.

Quite a introduction.