Hi OvF, yes you are right. Most BP would not want to let go of their underlying patents, so sometimes, what they do is to come up with a 'new invention' that is based on the old patent, as a way to indirectly extend the life of the underlying. So it depends on whether they can come up with such new invention.
I'm not sure how a new combination therapy would be treated, potentially it could lead to a patent in itself, a new combination therapy for treatment of x cancer, such that if anyone wants to use that combination, they would have to licence it from the owners. So, it could be a situation where there is a patent owned by IMU for its immunotherapy, a patent owned by BP for their existing drug, and a patent for the combination (which may be a joint patent). I am not too sure about this last bit, but it is possible. It was a long while ago when I was in this field.
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